Metabolism to a response pathway selective retinoid ligand during axial pattern formation
نویسندگان
چکیده
منابع مشابه
Metabolism to a response pathway selective retinoid ligand during axial pattern formation.
We report identification of 9-cis-4-oxo-retinoic acid (9-cis-4-oxo-RA) as an in vivo retinoid metabolite in Xenopus embryos. 9-Cis-4-oxo-RA bound receptors (RARs) alpha, beta, and gamma as well as retinoid X receptors (RXRs) alpha, beta, and gamma in vitro. However, this retinoid displayed differential RXR activation depending on the response pathway used. Although it failed to activate RXRs in...
متن کاملRetinoid metabolism during development of liver cirrhosis.
The changes in retinoid metabolism have been documented in liver cirrhosis. However, the dynamic alterations in levels of this vitamin between circulation and liver during development of the liver cirrhosis are not well understood. The aim of this study was to measure retinoids in the liver and circulation in parallel, during and after development of cirrhosis induced by carbon tetrachloride an...
متن کاملSelective Speciation of Ferric Iron by a New Heterocyclic Ligand
The synthesis and analytical applications of the new heterocyclic ligand are described. The complexation reaction of the ligand with some cations was studied in aqueous methanol at room temperature using the spectrophotometric method. Results revealed that only the absorption spectra of the Fe (III)–ligand complex show a high redshift of the absorption maximum in the aqueous methanol soluti...
متن کاملLigand-bound RXR can mediate retinoid signal transduction during embryogenesis.
Retinoids regulate various aspects of vertebrate development through the action of two types of receptors, the retinoic acid receptors (RARs) and the retinoid-X-receptors (RXRs). Although RXRs bind 9-cis-retinoic acid (9cRA) with high affinity, in vitro experiments suggest that RXRs are for the most part not liganded, but serve as auxiliary factors forming heterodimers with liganded partner rec...
متن کاملA structural view of ligand binding to the retinoid receptors
Nuclear receptors play an important role in transcription regulation. They bind as homoor heterodimers to the response elements of their target genes and interact with numerous and diverse partners, e. g. coactivator and corepressor proteins, and transcription factors. Many of these processes are ligand-dependent, i. e. binding of natural ligands activates the nuclear receptor through conformat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.26.15424